How to Diablo 4 Items Access Hoard: Collect 3x Pincushioned Dolls via:

Lord Zir's Hoard
Undercity of Kurast (via Tribute of Titans).

Loot: Can drop the Ophidian Iris and other powerful Sorcerer gear.

Harbinger of Hatred (New Boss)

Location: Harbinger's Den, deep jungles of Nehantu.

How to Access Hoard: Collect 3x Abhorrent Hearts from:

Undercity of Kurast
Hoard of Urivar.

Loot: Among the highest drop chances for top-tier Uniques like Ophidian Iris.

Tip: These bosses are extremely powerful. Bring a well-geared party and stack defenses.

2. Participate in World Events and Helltides

Helltides

Use Aberrant Cinders to open Tortured Gifts (chests).
Increased drop rates for high-rarity items, including Uniques.
Events happen every hour-make sure to spend your Cinders before time runs out, as they don't carry over.

Legion Events & Strongholds

High enemy density and better loot tables make these prime farming spots.
Combine with Elixirs and Shrines for improved drop chances.

Nightmare Dungeons & Strongrooms

Bonus loot tables based on tier.
Guaranteed high-level gear if you push deeper content.

3. Gamble with Obols at the Purveyor of Curiosities

Spend Murmuring Obols on Amulet rolls.
There's a small chance to pull a Unique, including Ophidian Iris.
Not guaranteed, but a decent sink for excess currency.
Best for post-level 85 when you've exhausted easier options.

Tip: Increase your odds by focusing only on Amulet pulls when you're hunting for the Ophidian Iris.

How to Build Around the Ophidian Iris

With Ophidian Iris, your Hydra Sorcerer evolves from a passive summoner into an active battlefield controller. Here's how to make the most of it:

Key Skills:

Hydra (now Core thanks to the amulet)
Firewall (optional for burning synergy)
Teleport or Flame Shield (for mobility/defense)
Inferno (Ultimate to group enemies for your Hydra)

Recommended Aspects & buy Diablo IV Items:

Aspect of the Embers - Burning synergy for additional DoT.
Flamescar Wand - Enhances burn and Fire damage.
Tal Rasha's Iridescent Loop - Bonus damage for elemental variance.
Raiment of the Infinite (optional) - Helps pull enemies into buy D4 materials Hydra AOE range.